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Last Updated: July 29, 2021

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Patent: 4,617,271

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Summary for Patent: 4,617,271
Title: Process for producing immobilized L-asparaginase preparations for the therapy of leukemia
Abstract:This invention relates to a process for producing immobilized L-asparaginase preparations. Its principal object is to produce immobilized L-asparaginase preparations which are excellent in antithrombogenicity and mechanical strength. The present invention is concerned with production of immobilized L-asparaginase preparations by pouring an aqueous solution containing 6% or more of a polyvinyl alcohol with a degree of hydrolysis of 97 mol. % or higher and a viscosity-average degree of polymerization of 1,800 or more an antileukemic asparaginase into a vessel or a mold of an appropriate shape, subjecting the solution to cooling, solidification and molding at a temperature of -15.degree. C. or lower and partially dehydrating the molded mass without thawing to a dehydration ratio of 5% by weight or more and, if desired, immersing the product in water. According to the invention, L-asparaginase can be embedded in a highly hydrous gel excellent in antithrombogenicity and mechanical strength by simple procedures.
Inventor(s): Nambu; Masao (Yokohama, JP)
Assignee: Nippon Oil Company, Limited (Tokyo, JP)
Application Number:06/573,922
Patent Claims:see list of patent claims

Details for Patent 4,617,271

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10 ⤷  Try it Free Nippon Oil Company, Limited (Tokyo, JP) 2003-10-14 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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Serving leading biopharmaceutical companies globally:

Boehringer Ingelheim
McKinsey
McKesson
Express Scripts
Merck
AstraZeneca

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