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Last Updated: January 24, 2020

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Patent: 4,616,658

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Summary for Patent: 4,616,658
Title: Non-radioactively labeled microspheres and use of same to measure blood flow
Abstract:A safe and inexpensive method of measuring blood flow in experimental animals using non-radioactively labeled microspheres is provided. The microspheres may be comprised of a variety of materials, including latex and agarose, and may be labeled with colored dyes or by linkage to enzymes, plant enzymes being preferred because they do not occur naturally in an animal\'s system. After injection and circulation of the microspheres throughout the animal\'s system, blood flow to particular tissue may be measured by counting the number of microspheres in the tissue sample, the initial number of microspheres in the animal\'s blood stream having been measured shortly after injection. In the case of microspheres labeled with colored dyes, the spheres may be counted in tissue either after separation from the tissue or while still trapped in the tissue\'s capillaries. Techniques for separating the microspheres from blood and tissue are also provided.
Inventor(s): Shell; William (Beverly Hills, CA), See; Jackie R. (Fullerton, CA)
Application Number:06/706,151
Patent Claims:see list of patent claims

Details for Patent 4,616,658

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial 2039-03-29 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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