Patent: 4,595,700

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Summary for Patent: 4,595,700

Title:	Thiol based collagenase inhibitors
Abstract:	This invention relates to compounds of the formula: ##STR1## wherein R.sub.1 represents lower alkyl, phenyl or phenyl lower alkyl; R.sub.2 and R.sub.4 represent lower alkyl; and R.sub.3 represents lower alkyl, benzyloxyalkyl, alkoxybenzyl or benzyloxybenzyl wherein the oxyalkyl or alkoxy moiety contain 1 to 6 carbon atoms; and a, b, and c represent chiral centers with optional R or S stereochemistry. These compounds inhibit collagenase and are useful in the treatment of arthritis. Also disclosed are processes for manufacture of the compounds and pharmaceutical compositions containing them.
Inventor(s):	Donald; David K. (High Wycombe, GB3), Hann; Michael M. (Watlington, GB3), Saunders; John (Ickford, GB3), Wadsworth; Harry J. (High Wycombe, GB3)
Assignee:	G. D. Searle & Co. (Skokie, IL)
Application Number:	06/703,973
Patent Claims:	see list of patent claims

Details for Patent 4,595,700

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Number	Approval Date	Patent No.	Assignee	Estimated Patent Expiration	Status	Orphan	Source
Smith And Nephew	SANTYL	collagenase	OINTMENT;TOPICAL	101995	001	1965-06-04	⤷ Free Forever Trial	G. D. Searle & Co. (Skokie, IL)	2004-12-21	RX		search
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Number	>Approval Date	>Patent No.	>Assignee	>Estimated Patent Expiration	>Status	>Orphan	>Source

International Patent Family for US Patent 4,595,700

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Country	Patent Number	Estimated Expiration
United States of America	4681966	⤷ Free Forever Trial
Japan	H0662554	⤷ Free Forever Trial
Japan	S61152650	⤷ Free Forever Trial
European Patent Office	0185380	⤷ Free Forever Trial
Germany	3577088	⤷ Free Forever Trial
Canada	1261867	⤷ Free Forever Trial
>Country	>Patent Number	>Estimated Expiration

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