Patent: 4,595,700

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Summary for Patent: 4,595,700

Title:	Thiol based collagenase inhibitors
Abstract:	This invention relates to compounds of the formula: ##STR1## wherein R.sub.1 represents lower alkyl, phenyl or phenyl lower alkyl; R.sub.2 and R.sub.4 represent lower alkyl; and R.sub.3 represents lower alkyl, benzyloxyalkyl, alkoxybenzyl or benzyloxybenzyl wherein the oxyalkyl or alkoxy moiety contain 1 to 6 carbon atoms; and a, b, and c represent chiral centers with optional R or S stereochemistry. These compounds inhibit collagenase and are useful in the treatment of arthritis. Also disclosed are processes for manufacture of the compounds and pharmaceutical compositions containing them.
Inventor(s):	Donald; David K. (High Wycombe, GB3), Hann; Michael M. (Watlington, GB3), Saunders; John (Ickford, GB3), Wadsworth; Harry J. (High Wycombe, GB3)
Assignee:	G. D. Searle & Co. (Skokie, IL)
Application Number:	06/703,973
Patent Claims:	see list of patent claims

Details for Patent 4,595,700

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Number	Approval Date	Patent No.	Assignee	Patent Expiration	Status	Orphan	Source
Advance Biofactures	SANTYL	collagenase	VIAL	101995	001	1965-06-04	➤ Try a Free Trial	G. D. Searle & Co. (Skokie, IL)	➤ Try a Free Trial	RX		search
Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Number	Approval Date	Patent No.	Assignee	Patent Expiration	Status	Orphan	Source

International Patent Family for US Patent 4,595,700

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Country	Patent Number	Publication Date
United States of America	4681966	Jul 21, 1987
Japan	H0662554	Aug 17, 1994
Japan	S61152650	Jul 11, 1986
European Patent Office	0185380	Apr 11, 1990
Country	Patent Number	Publication Date

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