Patent: 4,595,700
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Summary for Patent: 4,595,700
| Title: | Thiol based collagenase inhibitors |
| Abstract: | This invention relates to compounds of the formula: ##STR1## wherein R.sub.1 represents lower alkyl, phenyl or phenyl lower alkyl; R.sub.2 and R.sub.4 represent lower alkyl; and R.sub.3 represents lower alkyl, benzyloxyalkyl, alkoxybenzyl or benzyloxybenzyl wherein the oxyalkyl or alkoxy moiety contain 1 to 6 carbon atoms; and a, b, and c represent chiral centers with optional R or S stereochemistry. These compounds inhibit collagenase and are useful in the treatment of arthritis. Also disclosed are processes for manufacture of the compounds and pharmaceutical compositions containing them. |
| Inventor(s): | Donald; David K. (High Wycombe, GB3), Hann; Michael M. (Watlington, GB3), Saunders; John (Ickford, GB3), Wadsworth; Harry J. (High Wycombe, GB3) |
| Assignee: | G. D. Searle & Co. (Skokie, IL) |
| Application Number: | 06/703,973 |
| Patent Claims: | see list of patent claims |
Details for Patent 4,595,700
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
|---|---|---|---|---|---|---|---|
| Smith & Nephew, Inc. | SANTYL | collagenase | Ointment | 101995 | 06/04/1965 | See Plans and Pricing | 2004-12-21 |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
