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Last Updated: February 7, 2023

Patent: 4,595,700


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Summary for Patent: 4,595,700
Title: Thiol based collagenase inhibitors
Abstract:This invention relates to compounds of the formula: ##STR1## wherein R.sub.1 represents lower alkyl, phenyl or phenyl lower alkyl; R.sub.2 and R.sub.4 represent lower alkyl; and R.sub.3 represents lower alkyl, benzyloxyalkyl, alkoxybenzyl or benzyloxybenzyl wherein the oxyalkyl or alkoxy moiety contain 1 to 6 carbon atoms; and a, b, and c represent chiral centers with optional R or S stereochemistry. These compounds inhibit collagenase and are useful in the treatment of arthritis. Also disclosed are processes for manufacture of the compounds and pharmaceutical compositions containing them.
Inventor(s): Donald; David K. (High Wycombe, GB3), Hann; Michael M. (Watlington, GB3), Saunders; John (Ickford, GB3), Wadsworth; Harry J. (High Wycombe, GB3)
Assignee: G. D. Searle & Co. (Skokie, IL)
Application Number:06/703,973
Patent Claims:see list of patent claims

Details for Patent 4,595,700

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Smith & Nephew, Inc. SANTYL collagenase Ointment 101995 06/04/1965 See Plans and Pricing 2004-12-21
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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