Patent: 4,499,065
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Summary for Patent: 4,499,065
| Title: | Chymopapain allergen and method |
| Abstract: | A chymopapain derivative having the enzymatic activity reduced by at least 95% while retaining the original allergenic activity of at least 90% is suitable for skin testing to detect allergic hypersensitivity to chymopapain and for treating patients exhibiting allergic hypersensitivity to chymopapain. The enzymatic activity can be blocked by reacting thiol groups of the enzyme with and iodoacetic acid, bromoacetic acid, or a salt, ester or amide derivative thereof, under conditions which block the undesirable enzymatic activity while retaining the desired allergenic activity. |
| Inventor(s): | Calenoff; Emanuel (Burlingame, CA), Jones; Ruth M. (Redwood City, CA), Tsay; Yuh-Geng (San Jose, CA), Beigler; Myron A. (Los Altos Hills, CA) |
| Assignee: | Axonica, Inc. (Mt. View, CA) |
| Application Number: | 06/489,898 |
| Patent Claims: | see list of patent claims |
Details for Patent 4,499,065
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
|---|---|---|---|---|---|---|---|
| Discure Medical, Llc | CHYMODIACTIN | chymopapain | For Injection | 018663 | 11/10/1982 | ⤷ Try a Trial | 2040-04-01 |
| Discure Medical, Llc | CHYMODIACTIN | chymopapain | For Injection | 018663 | 08/21/1984 | ⤷ Try a Trial | 2040-04-01 |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
