Immobilization of active protein by cross-linking to inactive protein
A solution of an active protein substance and an inactive protein substance is reacted with a cross-linking agent, optionally in the presence of an inert carrier, under cross-linking conditions to produce articles comprising both active and inactive protein substances. The active protein substance comprises up to about 20 percent, e.g. from 1 to 20 percent by weight, based on the final weight of the total protein substance, whereas the cross-linking agent comprises from 0.5 to 8 percent by weight, based on the weight of the total treated mixture. The obtained articles are in the form of a solution or a suspension in aqueous medium, in the form of a film, in the form of a membrane, in the form of a fabric, in the form of a porous material, or in the form of a mass, such as granules, pills or tablets.
Avrameas; Stratis (La Celle Saint Cloud, FR), Broun; Georges (Rouen, FR), Selegny; Eric (Rouen, FR), Thomas; Daniel (Rouen, FR)
Agence Nationale de Valorisation de la Recherche (ANVAR) (Neuilly-sur-Seine, FR)
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