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Last Updated: February 1, 2023

Patent: 4,464,468


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Summary for Patent: 4,464,468
Title: Immobilization of active protein by cross-linking to inactive protein
Abstract:A solution of an active protein substance and an inactive protein substance is reacted with a cross-linking agent, optionally in the presence of an inert carrier, under cross-linking conditions to produce articles comprising both active and inactive protein substances. The active protein substance comprises up to about 20 percent, e.g. from 1 to 20 percent by weight, based on the final weight of the total protein substance, whereas the cross-linking agent comprises from 0.5 to 8 percent by weight, based on the weight of the total treated mixture. The obtained articles are in the form of a solution or a suspension in aqueous medium, in the form of a film, in the form of a membrane, in the form of a fabric, in the form of a porous material, or in the form of a mass, such as granules, pills or tablets.
Inventor(s): Avrameas; Stratis (La Celle Saint Cloud, FR), Broun; Georges (Rouen, FR), Selegny; Eric (Rouen, FR), Thomas; Daniel (Rouen, FR)
Assignee: Agence Nationale de Valorisation de la Recherche (ANVAR) (Neuilly-sur-Seine, FR)
Application Number:06/369,253
Patent Claims:see list of patent claims

Details for Patent 4,464,468

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Recordati Rare Diseases, Inc. ELSPAR asparaginase For Injection 101063 01/10/1978 See Plans and Pricing 2001-08-07
Smith & Nephew, Inc. SANTYL collagenase Ointment 101995 06/04/1965 See Plans and Pricing 2001-08-07
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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