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Last Updated: September 20, 2020

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Patent: 4,456,590

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Summary for Patent: 4,456,590
Title: Heat treatment of lyophilized blood clotting factor VIII concentrate
Abstract:A method for treating blood products to eliminate hepatitis virus present therein is disclosed. Blood products treated according to the method are first lyophilized and then subjected to heat for a period of time sufficient to inactivate the hepatitis virus. At the conclusion of the heating step the blood product can be reconstituted using sterile water or a like diluent. No adverse effects on blood product activity following treatment have been observed. The method has special applicability to blood plasma fractions such as Factor VIII, Factor IX and fibrinogen.
Inventor(s): Rubinstein; Alan (Houston, TX)
Assignee: Cedars Sinai Medical Center (Los Angeles, CA)
Application Number:06/377,863
Patent Claims:see list of patent claims

Details for Patent 4,456,590

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck Sharp & Dohme Corp. ZOSTAVAX zoster vaccine live INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION 125123 001 2006-05-25   Start Trial Cedars Sinai Medical Center (Los Angeles, CA) 2001-06-26 search
Merck Sharp & Dohme Corp. ZOSTAVAX zoster vaccine live INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION 125123 1 2006-05-25   Start Trial Cedars Sinai Medical Center (Los Angeles, CA) 2001-06-26 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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