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Last Updated: November 28, 2021

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Patent: 4,442,133

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Summary for Patent: 4,442,133
Title: Antibiotic bonding of vascular prostheses and other implants
Abstract:A method of preparing a surgical vascular graft wherein a length of graft material carries an absorbed coating of tridodecyl methyl ammonium chloride (TDMAC) surfactant and an antibiotic bound thereto. A length of graft material such as polytetrafluoroethylene or Dacron is soaked in a 5% by weight solution of TDMAC for 30 minutes at room temperature, air dried and then washed in distilled water to remove excess TDMAC. The graft carrying the absorbed cationic TDMAC surfactant coating is incubated in a solution of negatively charged antibiotic for one hour, washed in sterile water to remove unbound antibiotic and stored for use in the operating room.
Inventor(s): Greco; Ralph S. (Basking Ridge, NJ), Harvey; Richard A. (East Brunswick, NJ)
Application Number:06/351,324
Patent Claims:see list of patent claims

Details for Patent 4,442,133

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. ZOSTAVAX zoster vaccine live For Injection 125123 2006-05-25 ⤷  Free Forever Trial 2039-09-23
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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Serving leading biopharmaceutical companies globally:

Express Scripts
Boehringer Ingelheim

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