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Last Updated: November 26, 2020

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Patent: 4,425,428

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Summary for Patent: 4,425,428
Title: Novel peptide and peptolide substrates for mammalian collagenase
Abstract:Method for determination of the enzyme collagenase by reacting the enzyme with a peptide or peptolide substrate having the following amino acid sequences: R.sub.1 -Pro-Leu-Gly-Ile-Leu-Gly-Leu-R.sub.2, R.sub.1 -Gly-Pro-Leu-Gly-Ile-Leu-Gly-Ala-R.sub.2, R.sub.1 -Pro-Leu-Gly(O-Ile)-Leu-R.sub.2, R.sub.1 -Pro-Leu-Gly(O-Leu)-Leu-R.sub.2, and R.sub.1 -Pro-Leu-Gly(O-Leu)-Ala-R.sub.2, wherein R.sub.1 is H or N-protecting group, and R.sub.2 is terminal amide, carboxyl or ester group.
Inventor(s): Weingarten; Harold I. (University City, MO)
Assignee: Monsanto Company (St. Louis, MO)
Application Number:06/485,762
Patent Claims:see list of patent claims

Details for Patent 4,425,428

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial Monsanto Company (St. Louis, MO) 2002-04-08 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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