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Last Updated: September 24, 2020

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Patent: 4,416,992

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Summary for Patent: 4,416,992
Title: Support matrices and immobilized enzyme systems
Abstract:Support matrices are prepared by titanating the surface hydroxyl groups of refractory inorganic oxides with a titanium tetrahalide, such as TiCl.sub.4, reacting each of the remaining halogens of the surface-titanated oxide with one of the amino groups of diamine, and thereafter reacting the remaining amino group with one of the functional groups of a dialdehyde or diisocyanate. Titanating is carried out by contacting a refractory inorganic oxide with titanium tetrahalide, preferably in the absence of a solvent for the titanium tetrahalide, removing excess and unreacted titanium tetrahalide and heating the titanated inorganic oxide at a temperature of from about 80.degree. C. to about 200.degree. C. in an inert atmosphere of nitrogen, argon or helium, or in a vacuum. Such support matrices may be used to bind enzymes, affording effective immobilized enzyme systems.
Inventor(s): Arena; Blaise J. (Des Plaines, IL), Rohrbach; Ronald P. (Forest Lake, IL)
Assignee: UOP Inc. (Des Plaines, IL)
Application Number:06/362,206
Patent Claims:see list of patent claims

Details for Patent 4,416,992

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial UOP Inc. (Des Plaines, IL) 2039-03-29 RX search
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial UOP Inc. (Des Plaines, IL) 2039-03-29 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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Serving leading biopharmaceutical companies globally:

Express Scripts
Johnson and Johnson

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