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Last Updated: July 24, 2021

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Patent: 4,356,267

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Summary for Patent: 4,356,267
Title: Enzyme immobilization in cellulosic hollow fibres
Abstract:Enzymes are immobilized in a bundle of cellulosic hollow fibres for use as a fibre-bundle dialyzer for purifying blood. Immobilization is carried out by circulating through the lumen of the fibres to activate the fibres an aqueous solution of sodium periodate at a concentration of 0.7-21 mg/ml, a circulation rate of 300-500 mm.sup.3 /minute/mm.sup.2, a temperature of 15.degree.-30.degree. C. and for a period not exceeding 70 minutes, removing excess sodium periodate by washing the fibres, and directly or indirectly anchoring an enzyme to the activated fibres. Washing is preferably carried out by circulating through the lumen of the fibres dionized water followed by a dilute aqueous solution of glycerol. The fibres containing an immobilized enzyme may be sterilized with a sterilizing agent.
Inventor(s): Callegaro; Lanfranco (Padova, IT), Boniolo; Antonio (Saluggia, IT), Denti; Ennio (Pino Torinese, IT), Rosa; Umberto (Turin, IT), Rossi; Valdano (San Benedetto Po, IT)
Assignee: Sorin Biomedica S.p.A. (Saluggia, IT)
Application Number:06/233,702
Patent Claims:see list of patent claims

Details for Patent 4,356,267

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10 ⤷  Free Forever Trial Sorin Biomedica S.p.A. (Saluggia, IT) 2000-02-13 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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