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Last Updated: June 1, 2020

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Patent: 4,315,988

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Summary for Patent: 4,315,988
Title: Thermophilic collagenases, thermophilic bacteria capable of producing thermophilic collagenases, and process for producing said collagenases
Abstract:This invention relates to a process for producing collagenase, which comprises aerobically cultivating a collagenase-producing bacterium belonging to the genus Bacillus, and recovering collagenase from the culture broth. This invention also provides a thermophilic bacterium of the genus Bacillus which has the ability to produce collagenase and which grows at a temperature of 42.degree. to 74.degree. C. and a pH of 5.0 to 9.0 and a novel thermophilic collagenase which does not substantially lose collagenase activity even when maintained for 1 hour at a temperature of 60.degree. C. in the presence of a calcium ion at a pH in the range of 6.5 to 8.5, and which has a molecular weight, determined by gel filtration, between those of cytochrome C and ovalbumin.
Inventor(s): Miwa; Naoto (Ami, JP), Masuda; Yoshiro (Kashiwa, JP), Kawarabuki; Seiichi (Ami, JP), Sai; Toshiyuki (Ami, JP), Saito; Takao (Tsuchiura, JP)
Assignee: Mitsubishi Petrochemical Co., Ltd. (Tokyo, JP)
Application Number:06/025,748
Patent Claims:see list of patent claims

Details for Patent 4,315,988

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial Mitsubishi Petrochemical Co., Ltd. (Tokyo, JP) 1999-02-16 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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