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Last Updated: September 27, 2020

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Patent: 4,230,697

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Summary for Patent: 4,230,697
Title: Virus-inactivated HGI-glycoprotein capable of stimulating proliferation and differentiation of human granulocyte, process for preparing same and leukopenia curative containing same
Abstract:A colony-stimulating factor having definite physical and chemical properties and a function of stimulating activity on human bone marrow cells to proliferate and differentiate, thereby forming granulocyte colonies, is obtained from human urine by concentrating the urine with respect to proteins contained therein by adsorption chromatography with silica gel, salting out with ammonium sulfate and other means, then removing impurities by adsorption on cation exchanger, and further purifying by ion exchanging chromatography on anion exchanger, gel filtrating chromatography with highly crosslinked gels, affinity chromatography with sugar affinitive adsorbents and electrophoresis. This substance is stable in the presence of a stabilizer such as albumin or urinary proteins, against heat-treatment of virus-inactivation and can be used as a leukopenia curative which is precluded from fear of virus-infection.
Inventor(s): Nishida; Masayuki (Osaka, JP), Funakoshi; Satoshi (Katano, JP), Ogasa; Katsuhiro (Yokohama, JP), Kuboyama; Morio (Tokyo, JP), Yanai; Nobuya (Tokyo, JP), Yamada; Muneo (Kodaira, JP)
Assignee: Morinaga Milk Industry Co. Ltd. (Tokyo, JP) The Green Cross Corporation (Osaka, JP)
Application Number:06/037,515
Patent Claims:see list of patent claims

Details for Patent 4,230,697

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Grifols Usa, Llc PLASBUMIN albumin (human) SOLUTION 101138 1 1994-09-26   Start Trial Morinaga Milk Industry Co. Ltd. (Tokyo, JP) The Green Cross Corporation (Osaka, JP) 1998-07-03 search
Baxalta Us Inc. FLEXBUMIN albumin human INJECTION, SOLUTION 101452 1 2014-07-31   Start Trial Morinaga Milk Industry Co. Ltd. (Tokyo, JP) The Green Cross Corporation (Osaka, JP) 1998-07-03 search
Csl Behring Ag ALBURX albumin (human) SOLUTION 102366 1 2009-01-06   Start Trial Morinaga Milk Industry Co. Ltd. (Tokyo, JP) The Green Cross Corporation (Osaka, JP) 1998-07-03 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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