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Last Updated: March 29, 2024

Patent: 10,590,182


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Summary for Patent: 10,590,182
Title:Binding-triggered transcriptional switches and methods of use thereof
Abstract: The present disclosure provides binding-triggered transcriptional switch polypeptides, nucleic acids comprising nucleotide sequences encoding the binding-triggered transcriptional switch polypeptides, and host cells genetically modified with the nucleic acids. The present disclosure also provides chimeric Notch receptor polypeptides, nucleic acids comprising nucleotide sequences encoding the chimeric Notch receptor polypeptides, and host cells transduced and/or genetically modified with the nucleic acids. The present disclosure provides transgenic organisms comprising a nucleic acid encoding a binding triggered transcriptional switch polypeptide and/or a chimeric Notch receptor polypeptide of the present disclosure. Binding triggered transcriptional switch polypeptides and chimeric Notch receptor polypeptides of the present disclosure are useful in a variety of applications, which are also provided.
Inventor(s): Lim; Wendell A. (San Francisco, CA), Morsut; Leonardo (San Francisco, CA), Roybal; Kole T. (San Francisco, CA), Farlow; Justin Thomas (San Francisco, CA), Toda; Satoshi (San Francisco, CA)
Assignee: The Regents of the University of California (Oakland, CA)
Application Number:15/543,220
Patent Claims:see list of patent claims

Details for Patent 10,590,182

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Janssen Biotech, Inc. REOPRO abciximab Injection 103575 12/22/1994 ⤷  Try a Trial 2035-02-24
Aytu Bioscience, Inc. PROSTASCINT capromab pendetide Injection 103608 10/28/1996 ⤷  Try a Trial 2035-02-24
Genentech, Inc. RITUXAN rituximab Injection 103705 11/26/1997 ⤷  Try a Trial 2035-02-24
Hoffmann-la Roche Inc. ZENAPAX daclizumab Injection 103749 12/10/1997 ⤷  Try a Trial 2035-02-24
Novartis Pharmaceuticals Corporation SIMULECT basiliximab For Injection 103764 05/12/1998 ⤷  Try a Trial 2035-02-24
Novartis Pharmaceuticals Corporation SIMULECT basiliximab For Injection 103764 01/02/2003 ⤷  Try a Trial 2035-02-24
Boehringer Ingelheim Pharmaceuticals, Inc. VERLUMA nofetumomab Injection 103769 10/13/1998 ⤷  Try a Trial 2035-02-24
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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