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Last Updated: September 28, 2020

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Patent: 10,545,138

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Summary for Patent: 10,545,138
Title:Stable nanomagnetic particle dispersions
Abstract: Processes and compositions are described for preparing new, colloidally stable, coated nanomagnetic particles useful for both in-vitro and in-vivo biomedical applications, including cell targeting and capturing cells, microorganisms, and cellular organelles or entities such as exosomes. These nanomagnetic particles can also be used as imaging contrast agents due to their small size and high magnetic moment. The nanomagnetic particles include a series of sequentially added, stabilizing surface coatings rendered onto nano-sized magnetic crystal clusters (e.g., magnetite particles) to impart colloidal stability in complex biological samples with minimal leaching of the coating materials, high binding capacity, and low non-specific binding. Another benefit of this invention is the ability to utilize both external and internal magnetic field-generating separation devices to effect separation of the magnetic nanoparticles.
Inventor(s): Gohel; Dhanesh (San Diego, CA), Zhang; Hong (La Jolla, CA), Ransom; John (Encinitas, CA)
Assignee: BioLegend, Inc. (San Diego, CA)
Application Number:15/143,552
Patent Claims:see list of patent claims

Details for Patent 10,545,138

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Grifols Usa, Llc HUMAN ALBUMIN GRIFOLS albumin (human) SOLUTION 103352 1 2003-06-11   Start Trial BioLegend, Inc. (San Diego, CA) 2040-01-28 search
Csl Behring Llc ALBUMINAR-25 albumin (human) SOLUTION 103955 1 2009-01-06   Start Trial BioLegend, Inc. (San Diego, CA) 2040-01-28 search
Octapharma Usa Inc ALBUMIN (HUMAN) albumin human SOLUTION 125154 1 2006-10-17   Start Trial BioLegend, Inc. (San Diego, CA) 2040-01-28 search
Kedrion S.p.a KEDBUMIN albumin (human) INJECTION, SOLUTION 125384 1 2011-09-15   Start Trial BioLegend, Inc. (San Diego, CA) 2040-01-28 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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