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Last Updated: September 27, 2020

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Patent: 10,537,635

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Summary for Patent: 10,537,635
Title:Detection of arginine methylation of EGFR for prediction of resistance to therapy
Abstract: This invention provides biomarkers (e.g., methylation of R198 or R200 of EGFR or the presence of an arginine at position 497 of EGFR) for the prediction of resistance to cetuximab therapy. This invention also provides methods for the selection of patients for combination therapy with cetuximab and PRMT inhibitors.
Inventor(s): Hung; Mien-Chie (Houston, TX), Liao; Hsin-Wei (Houston, TX), Hsu; Jung-Mao (Houston, TX)
Assignee: Board of Regents, The University of Texas System (Austin, TX)
Application Number:15/036,797
Patent Claims:see list of patent claims

Details for Patent 10,537,635

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Imclone ERBITUX cetuximab VIAL; INTRAVENOUS 125084 001 2004-06-18   Start Trial Board of Regents, The University of Texas System (Austin, TX) 2033-11-19 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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