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Last Updated: September 27, 2020

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Patent: 10,537,620

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Summary for Patent: 10,537,620
Title:Site-specific polyethylene glycolylated (pegylated) asparaginase, preparation method therefor and use thereof
Abstract: The present application discloses a PEGylated asparaginase and use thereof. In this application, the polyethylene glycol (PEG) is coupled to the N-terminal amino of 1 or 2 subunits of L-asparaginase, and the molecular weight of the PEG is 30-40 KDa. The PEG is preferably branched and has an aldehyde group serving as an activating group. The PEGylated asparaginase is useful in the preparation of anti-tumor drugs.
Inventor(s): Ma; Bruce Yong (Changzhou, CN), Wang; Jun (Changzhou, CN), Wang; He (Changzhou, CN), Xu; Chunlin (Changzhou, CN), Chen; Yifei (Changzhou, CN), Wang; Yaofang (Changzhou, CN)
Assignee: ZONHON BIOPHARMA INSTITUTE INC. (Changzhou, CN) GENSUN INSTITUTE OF BIOMEDICINE CO., LTD. (Changzhou, CN)
Application Number:15/522,445
Patent Claims:see list of patent claims

Details for Patent 10,537,620

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial ZONHON BIOPHARMA INSTITUTE INC. (Changzhou, CN) GENSUN INSTITUTE OF BIOMEDICINE CO., LTD. (Changzhou, CN) 2034-12-29 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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