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Last Updated: September 24, 2020

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Patent: 10,500,256

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Summary for Patent: 10,500,256
Title:Polymers for delivery of therapeutic proteins
Abstract: In some aspects, improved hydrogel copolymers (e.g., comprising itaconic acid and N-vinylpyrrolidone) are provided and may be used, e.g., for oral delivery of a therapeutic protein. In some embodiments, improved methods for loading a therapeutic protein (e.g., a high isoelectric point protein) into a hydrogel copolymer are provided, and may comprise incubating the therapeutic protein and the hydrogel in a reduced ionic strength loading solution. In some embodiments, use of the reduced ionic strength loading solution can result in hydrogel copolymer-therapeutic protein compositions that display improved pharmacokinetic attributes, e.g., improved loading and/or release of a therapeutic protein.
Inventor(s): Koetting; Michael (Austin, TX), Peppas; Nicholas (Austin, TX)
Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, TX)
Application Number:14/870,807
Patent Claims:see list of patent claims

Details for Patent 10,500,256

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech RITUXAN rituximab SOLUTION;INTRAVENOUS 103705 001 1997-11-26   Start Trial BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, TX) 2034-09-30 RX search
Genentech RITUXAN rituximab SOLUTION;INTRAVENOUS 103705 002 1997-11-26   Start Trial BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, TX) 2034-09-30 RX search
Novartis SIMULECT basiliximab VIAL; SINGLE-USE 103764 001 1998-05-12   Start Trial BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, TX) 2034-09-30 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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Serving leading biopharmaceutical companies globally:

Merck
Moodys
McKinsey
Mallinckrodt
Johnson and Johnson
Boehringer Ingelheim

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