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Last Updated: September 18, 2020

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Patent: 10,487,129

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Summary for Patent: 10,487,129
Title:Stabilized insulinotropic peptides and methods of use
Abstract: The present invention provides stably crosslinked insulinotropic polypeptides having superior and unexpected benefits in the treatment of conditions involving abnormal glucose homeostasis, e.g., type 2 diabetes and conditions relating to type 2 diabetes. Such benefits include, but are not limited to, extended polypeptide half-life, enhanced alpha-helicity, improved thermal stability and protease resistance, increased functional activity and pharmacologic properties, improved bioavailability when administered by any route, and improved bioavailability and gastrointestinal absorption when delivered orally, as compared to the corresponding unmodified polypeptides. The invention also provides compositions for administering the polypeptides of the invention, as well as methods for preparing and evaluating the polypeptides of the invention.
Inventor(s): Walensky; Loren D. (Newton, MA), Bird; Gregory (Pelham, NH)
Assignee: DANA-FARBER CANCER INSTITUTE, INC. (Boston, MA)
Application Number:15/608,053
Patent Claims:see list of patent claims

Details for Patent 10,487,129

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Glaxosmithkline Llc TANZEUM albiglutide INJECTABLE;INJECTION 125431 001 2014-04-15   Start Trial DANA-FARBER CANCER INSTITUTE, INC. (Boston, MA) 2029-01-23 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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