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Last Updated: November 29, 2021

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Patent: 10,487,128

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Summary for Patent: 10,487,128
Title:Conjugate of biologically active polypeptide monomer and immunoglobulin Fc fragment with reduced receptor-mediated clearance, and the method for preparing the same
Abstract: Provided is a long-acting pharmaceutical composition containing a conjugate comprising a physiologically active polypeptide linked to an immunoglobulin Fc fragment, wherein the composition contains a monomeric conjugate comprising one molecule of the physiologically active polypeptide linked to a single immunoglobulin Fc fragment, and optionally contains a multimeric conjugate comprising two or more molecules of the same physiologically active polypeptide linked to a single immunoglobulin Fc fragment, provided that the molar ratio of the monomeric conjugate to the multimeric conjugate in the composition is at least 19; a physiologically active polypeptide monomer-immunoglobulin Fc fragment conjugate that comprises a physiologically active polypeptide monomer linked via a non-peptidyl linker to an immunoglobulin Fc fragment, wherein the physiologically active polypeptide is linked via the non-peptidyl linker to the immunoglobulin Fc fragment in a monomeric form.
Inventor(s): Park; Sung Hee (Seongnam-si, KR), Kim; Min Young (Anseong-si, KR), Lim; Hyung Kyu (Hwaseong-si, KR), Bae; Sung Min (Seongnam-si, KR), Jung; Sung Youb (Suwon-si, KR), Kwon; Se Chang (Seoul, KR)
Assignee: HANMI PHARM. CO., LTD (Hwaseong-Si, KR)
Application Number:14/904,254
Patent Claims:see list of patent claims

Details for Patent 10,487,128

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Microbix Biosystems Inc. KINLYTIC urokinase For Injection 021846 1978-01-16 ⤷  Try it Free 2033-07-12
Nps Pharmaceuticals, Inc. NATPARA parathyroid hormone For Injection 125511 2015-01-23 ⤷  Try it Free 2033-07-12
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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Serving leading biopharmaceutical companies globally:

Johnson and Johnson
Express Scripts
Harvard Business School

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