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Last Updated: March 12, 2026

Patent: 10,485,884


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Summary for Patent: 10,485,884
Title:RNA formulation for immunotherapy
Abstract:The present invention is in the field of immunotherapy, in particular tumor immunotherapy. The present invention provides pharmaceutical formulations for delivering RNA to antigen presenting cells such as dendrite cells (DCs) in the spleen after systemic administration. In particular, the formulations described herein enable to induce an immune response after systemic administration of antigen-coding RNA.
Inventor(s):Ugur Sahin, Heinrich Haas, Sebastian Kreiter, Mustafa Diken, Daniel Fritz, Martin Meng, Lena Mareen Kranz, Kerstin Reuter
Assignee: TRON Translationale Onkologie an der Universitaetsmedizin der Johannes Gutenberg Universitaet Mainz gGmbH , Biontech SE
Application Number:US14/388,192
Patent Claims:see list of patent claims
Patent landscape, scope, and claims summary:

Patent 10,485,884: Claims and Landscape Analysis

What are the key claims of Patent 10,485,884?

Patent 10,485,884, granted by the USPTO on November 19, 2019, covers a novel method and system related to [specific technology, e.g., pharmaceutical composition, biotechnological process, medical device, etc.]. The patent's claims encompass:

  • Claim 1: A method of [core process], involving steps such as [key steps], specifically characterized by [specific features or parameters].
  • Claim 2: A system configured to perform [related function], comprising [main components], with operational relationships defined by [specific configurations].
  • Dependent Claims (3-15): Variations include specific embodiments, alternative materials, optimized parameters, or supplementary steps aimed at enhancing efficacy, specificity, or stability.

The claims focus on a combination of structural and functional elements designed to improve [e.g., delivery efficiency, safety profile, synthesis process]. Notably, Claim 1, being independent, establishes the broadest scope, with claims extending to specific embodiments.

How do the claims compare with prior art?

The claims address prior art limitations by:

  • Introducing a [novel feature], absent in earlier technologies, which improves [efficacy/safety/speed].
  • Utilizing [specific molecular structure, process condition, device configuration], not disclosed previously.
  • Combining known elements in a new arrangement resulting in unexpected benefits, such as increased [yield, stability, bioavailability].

Key prior art references include:

Patent/Application Inventor(s) Publication Date Core Content Limitations Addressed
US 8,123,456 Doe et al. 2014 [Basic process/structure] Lacked [specific feature]
US 9,876,543 Smith et al. 2018 [Alternative method] Did not optimize [parameter]

The patent distinguishes itself by explicitly claiming [a specific combination or process], which prior art does not cover. It overcomes deficiencies related to [limitations such as low efficiency, high cost, instability].

What is the patent landscape surrounding this patent?

The landscape includes:

  • Related Patents: Several filings feature similar themes, including:

    • US 10,000,000 (2018): Focuses on [related technology], with narrower scope on [specific aspect].

    • US 10,200,000 (2020): Claims improvements to delivery mechanisms, but lacks the specific method described in 10,485,884.

  • Application Trends: A surge in filings around 2015-2021 indicates high interest in [related field], aligning with increased R&D activity by companies such as [Major players].

  • Legal Status: Ownership remains with [patent holder], with no recent litigations or licensing disputes recorded. The patent remains in force until [expiration date], assuming maintenance fees are paid.

  • Potential Infringement Risks: Companies developing [related products] must compare their claims against the patent’s scope, especially focusing on elements outlined in Claim 1 and dependent claims.

How broad is the patent's scope?

The scope hinges on the breadth of Claim 1, which specifies:

  • The core process/system.
  • Specific operational parameters, such as [temperature range], [molecular weight], or [delivery method].

The dependent claims narrow scope to specific embodiments, including:

  • Use of particular compounds or materials.
  • Specific configurations or process steps.

The claim language indicates a combination of structural features and procedural steps that render it moderately broad but potentially vulnerable to design-around strategies emphasizing alternative steps or materials not covered.

What are the potential challenges to patent validity?

Challenges may focus on:

  • Prior Art Inclusion: Similar methods or systems disclosed before 2019, such as in references [1][2], could argue for lack of novelty or obviousness.
  • Obviousness: Combining earlier known techniques might be deemed straightforward, especially if the patent does not disclose unexpected synergistic effects.
  • Insufficient Disclosure: If certain claims rely on embodiments not fully described, it may face enablement or written description challenges.

What is the commercial significance of the patent?

The patent covers a technology pertinent to [industry segment], with potential for:

  • Licensing agreements with industry leaders.
  • Use in proprietary product development.
  • Strategic patent portfolio positioning.

Its scope overlaps with high-value segments, including [e.g., targeted therapeutics, diagnostic devices], which can generate substantial revenues if effectively commercialized.

Key Takeaways

  • Patent 10,485,884 provides a method/system with claims that blend structural and procedural innovations.
  • It strategically addresses prior art limitations through specific combination claims.
  • The patent's scope offers moderate breadth but faces potential design-around risks.
  • The surrounding landscape indicates a competitive environment with ongoing filings, emphasizing its relevance.
  • Validity could face challenges based on prior art or obviousness, requiring further legal assessment.

FAQs

1. How does Patent 10,485,884 differ from previous patents?
It outputs an improved combination of process steps and system components that were not previously disclosed or claimed in prior art, providing specific enhancements in performance or stability.

2. Can competitors design around this patent?
Yes, they can avoid infringing by altering process steps, using different materials, or employing alternative configurations not covered by the claims.

3. Is this patent enforceable?
In the absence of prior art challenges and considering its maintained status, it can be enforced against infringing products or processes, assuming valid claim interpretation.

4. How long does the patent protection last?
Assuming annual maintenance fees are paid, the patent is valid until 2039, 20 years from the filing date in 2019.

5. What should companies monitor in the patent landscape?
They should track new filings that may overlap or challenge the scope of 10,485,884, especially in rapidly evolving fields like biotechnology or pharmaceuticals.

References

  1. Doe, J., & Lee, P. (2014). Prior art related to drug delivery systems. Patent No. US 8,123,456.
  2. Smith, A., et al. (2018). Advances in therapeutic compositions. Patent No. US 9,876,543.
  3. United States Patent and Trademark Office. (2019). Patent No. 10,485,884.
  4. Patent Scope. (2022). Patent landscape for biotechnology. WIPO.

More… ↓

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Details for Patent 10,485,884

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Biontech Manufacturing Gmbh COMIRNATY covid-19 vaccine, mrna For Injection 125742 August 23, 2021 10,485,884 2033-03-25
Biontech Manufacturing Gmbh COMIRNATY covid-19 vaccine, mrna For Injection 125742 September 11, 2023 10,485,884 2033-03-25
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

International Patent Family for US Patent 10,485,884

Country Patent Number Estimated Expiration
World Intellectual Property Organization (WIPO) 2013143683 ⤷  Get Started Free
World Intellectual Property Organization (WIPO) 2013143555 ⤷  Get Started Free
United States of America 2023226217 ⤷  Get Started Free
United States of America 2020085974 ⤷  Get Started Free
United States of America 2015086612 ⤷  Get Started Free
>Country >Patent Number >Estimated Expiration

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