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Last Updated: September 24, 2020

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Patent: 10,485,793

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Summary for Patent: 10,485,793
Title:Regimen for suppressing organ rejection
Abstract: The present invention relates to a method of suppressing organ rejection in a patient receiving an organ transplant by initiating oral treatment with a once-daily extended release tacrolimus dosage form, for example, at an initial dose of from about 0.15 to about 0.20 mg/kg/day within 24 or 48 hours following transplantation. The once-daily extended release tacrolimus dosage form (i) provides low fluctuation and/or swing of tacrolimus, (ii) provides a significantly lower C.sub.max than an immediate release formulation of tacrolimus while providing the same or greater area under the curve (AUC), (iii) releases the tacrolimus substantially in the colon and/or the lower ileum, (iv) releases at most 63.5% of the tacrolimus in the dosage form at the 12 hour time point, or (v) any combination of any of the foregoing.
Inventor(s): Polvino; William J. (Edison, NJ)
Assignee: VELOXIS PHARMACEUTICALS A/S (Kobenhavn, DK)
Application Number:15/682,275
Patent Claims:see list of patent claims

Details for Patent 10,485,793

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Novartis SIMULECT basiliximab VIAL; SINGLE-USE 103764 001 1998-05-12   Start Trial VELOXIS PHARMACEUTICALS A/S (Kobenhavn, DK) 2033-06-27 RX search
Novartis SIMULECT basiliximab VIAL; SINGLE-USE 103764 002 1998-05-12   Start Trial VELOXIS PHARMACEUTICALS A/S (Kobenhavn, DK) 2033-06-27 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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