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Last Updated: September 28, 2020

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Patent: 10,472,599

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Summary for Patent: 10,472,599
Title:Microfluidic cell culture of patient-derived tumor cell spheroids
Abstract: Provided herein are methods for culturing patient-derived tumor cell spheroids in a three-dimensional microfluidic device. The method comprises mincing primary tumor sample in a medium supplemented with serum; treating the minced primary tumor sample with a composition comprising an enzyme; collecting tumor spheroids having a diameter of 10 .mu.m to 500 .mu.m from the enzyme treated sample; suspending the tumor spheroids in biocompatible gel; and culturing the tumor spheroids in a three dimensional microfluidic device. Methods for identifying an agent for treating cancer and microfluidic devices that allow for the simultaneous exposure of the cultured patient-derived primary tumor cell spheroids to a treatment of choice and to control treatment are also provided.
Inventor(s): Barbie; David (Andover, MA), Aref; Amir (Malden, MA), Barbie; Thanh (Andover, MA), Jenkins; Russell W. (Boston, MA), Wong; Kwok-kin (Arlington, MA)
Assignee: Dana-Farber Cancer Institute, Inc. (Boston, MA)
Application Number:15/540,346
Patent Claims:see list of patent claims

Details for Patent 10,472,599

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial Dana-Farber Cancer Institute, Inc. (Boston, MA) 2035-01-07 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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Serving leading biopharmaceutical companies globally:

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Johnson and Johnson

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