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Last Updated: September 27, 2020

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Patent: 10,441,611

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Summary for Patent: 10,441,611
Title:Method for producing amniotic mesenchymal stromal cell composition, method for cryopreserving the same, and therapeutic agent
Abstract: An object of the present invention is to provide a method for producing a mesenchymal stromal cell composition, comprising conveniently and aseptically separating high-purity amnion-derived MSCs by performing enzyme treatment only once. According to the present invention, the following are provided: a method for producing a mesenchymal stromal cell composition, comprising: performing enzyme treatment of an amnion with collagenase and thermolysin and/or dispase; and filtering the enzyme-treated amnion through a mesh; a method for producing a cryopreserved mesenchymal stromal cell composition; and a therapeutic agent comprising as an active ingredient the mesenchymal stromal cell composition for a disease selected from graft-versus-host disease, inflammatory bowel disease, systemic lupus erythematosus, liver cirrhosis, or radiation enteritis.
Inventor(s): Yamahara; Kenichi (Suita, JP), Taguchi; Akihiko (Kobe, JP), Soma; Toshihiro (Nishinomiya, JP), Ohnishi; Shunsuke (Sapporo, JP), Kobayashi; Akira (Takasago, JP)
Assignee: NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER (Suita-shi, JP) FOUNDATION FOR BIOMEDICAL RESEARCH AND INNOVATION AT KOBE (Kobe-shi, JP) HYOGO COLLEGE OF MEDICINE (Nishinomiya-shi, JP) NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Sapporo-shi, JP) KANEKA CORPORATION (Osaka-shi, JP)
Application Number:14/912,662
Patent Claims:see list of patent claims

Details for Patent 10,441,611

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER (Suita-shi, JP) FOUNDATION FOR BIOMEDICAL RESEARCH AND INNOVATION AT KOBE (Kobe-shi, JP) HYOGO COLLEGE OF MEDICINE (Nishinomiya-shi, JP) NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Sap 2033-08-19 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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