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Last Updated: December 5, 2021

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Patent: 10,426,817

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Summary for Patent: 10,426,817
Title:Treatment of age-related macular degeneration and other eye diseases with apolipoprotein mimetics
Abstract: The present disclosure provides apolipoprotein (apo) mimetics useful for the treatment of age-related macular degeneration (AMD) and other eye disorders. The apo mimetics can be peptides/polypeptides that mimic, e.g., the lipid-clearing action of apolipoproteins such as apoA-I and apoE. The apo mimetics can exert other beneficial effects, such as reduction of inflammation, oxidative stress and neovascularization. The apo mimetics can be used to treat any stages (including the early, intermediate and advance stages) of AMD, and any phenotypes of AMD, including geographic atrophy (GA) (including non-central GA and central GA) and neovascularization (NV) (including types 1, 2 and 3 NV). The apo mimetics can be used alone or in conjunction with other therapeutic agents, such as a complement inhibitor and/or an anti-angiogenic agent, to treat AMD, including atrophic AMD and neovascular AMD, and other eye disorders.
Inventor(s): Rudolf; Martin (Luebeck, DE), Roizman; Keith (San Jose, CA)
Assignee: MacRegen, Inc. (San Jose, CA)
Application Number:15/414,422
Patent Claims:see list of patent claims

Details for Patent 10,426,817

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. AVASTIN bevacizumab Injection 125085 2004-02-26 ⤷  Try it Free 2039-10-23
Genentech, Inc. LUCENTIS ranibizumab Injection 125156 2006-06-30 ⤷  Try it Free 2039-10-23
Genentech, Inc. LUCENTIS ranibizumab Injection 125156 2012-08-10 ⤷  Try it Free 2039-10-23
Genentech, Inc. LUCENTIS ranibizumab Injection 125156 2016-10-13 ⤷  Try it Free 2039-10-23
Genentech, Inc. LUCENTIS ranibizumab Injection 125156 2018-03-20 ⤷  Try it Free 2039-10-23
Regeneron Pharmaceuticals, Inc. EYLEA aflibercept Injection 125387 2011-11-18 ⤷  Try it Free 2039-10-23
Regeneron Pharmaceuticals, Inc. EYLEA aflibercept Injection 125387 2018-08-16 ⤷  Try it Free 2039-10-23
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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