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Last Updated: September 29, 2020

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Patent: 10,420,761

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Summary for Patent: 10,420,761
Title:Allosteric inhibitors of thymidylate synthase
Abstract: The current invention is directed to a class of compounds that inhibit the function of Thymidylate synthase. Thymidylate synthase inhibition was noted to result in inhibition of tumor cell grow and killing of tumor cells. Thymidylate synthase inhibition is, thus, useful for treatment of various types of cancers, including but not limited to, acute lymphoblatic leukemia (ALL), acute myelogenous leukemia (AML), acute promyelocytic leukemia, chronic lymphocytic leukemia (CLL), chronic myelogenous leukemia (CML), acute monocytic leukemia (AMOL), hairy cell leukemia, large cell immunoblastic lymphoma, plasmacytoma, multiple myeloma, Hodgkin\'s lymphoma, non-Hodgkin\'s lymphoma, leukemia, brain cancer, lung cancer, central nervous system (CNS) cancer, melanoma, renal cancer, prostate cancer, colon cancer, ovarian cancer and breast cancer. The compounds disclosed herein can be used alone or in combination with other cancer treatment regimens (e.g., radiation therapy and/or other chemotherapeutic agents that are administered to a subject having a tumor, cancer or neoplasia).
Inventor(s): Zajac-Kaye; Maria (Gainesville, FL), Kulemina; Lidia (Destin, FL)
Assignee: University of Florida Research Foundation, Inc. (Gainesville, FL)
Application Number:14/773,906
Patent Claims:see list of patent claims

Details for Patent 10,420,761

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Chiron PROLEUKIN aldesleukin VIAL 103293 001 1992-05-05   Start Trial University of Florida Research Foundation, Inc. (Gainesville, FL) 2033-03-15 RX search
Amgen NEUPOGEN filgrastim VIAL 103353 001 1991-02-20   Start Trial University of Florida Research Foundation, Inc. (Gainesville, FL) 2033-03-15 RX search
Amgen NEUPOGEN filgrastim VIAL 103353 002 1991-02-20   Start Trial University of Florida Research Foundation, Inc. (Gainesville, FL) 2033-03-15 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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