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Last Updated: September 30, 2020

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Patent: 10,406,235

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Summary for Patent: 10,406,235
Title:Use of multi-arm polyethylene glycol modifier and application of multi-arm polyethylene glycol modifier in L-asparaginasum modification
Abstract: Methods for use of a multi-arm polyethylene glycol (PEG) modifier in modification of asparaginase. The described multi-arm PEG modifier enhances the subunit interaction of a multimeric protein to maintain the multimeric protein in a polymerized form, thereby improving the stability of the multimeric protein, maintaining the bioactivity of the multimeric protein, and reducing the probability of exposure of the antigen binding site after depolymerization of the subunits, so as to reduce the immunogenicity.
Inventor(s): Ma; Bruce Yong (Jiangsu, CN), Wang; Jun (Jiangsu, CN), Wu; Dinglong (Jiangsu, CN), Xu; Chunlin (Jiangsu, CN), Wang; Yaofang (Jiangsu, CN)
Assignee: ZONHON BIOPHARMA INSTITUTE INC. (Changzhou, CN) GENSUN INSTITUTE OF BIOMEDICINE CO., LTD. (Changzhou, CN)
Application Number:15/109,304
Patent Claims:see list of patent claims

Details for Patent 10,406,235

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial ZONHON BIOPHARMA INSTITUTE INC. (Changzhou, CN) GENSUN INSTITUTE OF BIOMEDICINE CO., LTD. (Changzhou, CN) 2033-12-30 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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