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Last Updated: September 22, 2020

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Patent: 10,385,139

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Summary for Patent: 10,385,139
Title:Murine, chimeric, humanized or human anti-TNF-alpha antibodies
Abstract: The present invention concerns compositions and methods of use of bispecific antibodies comprising at least one anti-TNF-.alpha. antibody or antigen-binding fragment thereof and at least one anti-IL-6 antibody or antigen-binding fragment thereof. Preferably, the bispecific antibody is in the form of a DNL.RTM. complex. The anti-TNF-.alpha. or anti-IL-6 antibodies may comprise specific CDR sequences disclosed herein. The compositions and methods are of use to treat autoimmune disease, immune system dysfunction or inflammatory disease, as disclosed herein.
Inventor(s): Goldenberg; David M. (Mendham, NJ), Li; Rongxiu (Parsippany, NJ), Chang; Chien-Hsing (Downingtown, PA)
Assignee: IBC Pharmaceuticals, Inc. (Morris Plains, NJ)
Application Number:15/897,847
Patent Claims:see list of patent claims

Details for Patent 10,385,139

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial IBC Pharmaceuticals, Inc. (Morris Plains, NJ) 2033-11-01 RX search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23   Start Trial IBC Pharmaceuticals, Inc. (Morris Plains, NJ) 2033-11-01 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23   Start Trial IBC Pharmaceuticals, Inc. (Morris Plains, NJ) 2033-11-01 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23   Start Trial IBC Pharmaceuticals, Inc. (Morris Plains, NJ) 2033-11-01 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 004 2015-01-23   Start Trial IBC Pharmaceuticals, Inc. (Morris Plains, NJ) 2033-11-01 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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