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Last Updated: September 30, 2020

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Patent: 10,378,059

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Summary for Patent: 10,378,059
Title:Methods and molecular pharmacodynamic biomarkers for multiple signaling pathways in response to carboxyamidotriazole orotate
Abstract: This invention provides methods, pharmacodynamics biomarker signatures for multiple signaling pathways in a cell sample such as anagen hair, in response to carboxyamidotriazole orotate (CTO) from a subject. CTO has demonstrated response in several cancers having different genomic mutations in clinical studies. This invention provides a diagnostic and prognostic assay for monitoring response to CTO ranging from -100 fold to +25 fold differential expression in several transcriptional signatures associated with tumor inhibition including EGFR, MEK, HDAC, RAS, GFS, WNT, HSP90 or non-voltage dependent calcium signaling, while inducing tumor suppressors signatures such as P53 or EGR1 in the anagen hair assay.
Inventor(s): Karmali; Rashida A (Brooklyn, NY)
Assignee: TACTICAL THERAPEUTICS, INC. (New York, NY)
Application Number:13/957,720
Patent Claims:see list of patent claims

Details for Patent 10,378,059

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 001 1978-01-16   Start Trial TACTICAL THERAPEUTICS, INC. (New York, NY) 2039-08-18 DISCN search
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 002 1978-01-16   Start Trial TACTICAL THERAPEUTICS, INC. (New York, NY) 2039-08-18 DISCN search
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 003 1978-01-16   Start Trial TACTICAL THERAPEUTICS, INC. (New York, NY) 2039-08-18 DISCN search
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial TACTICAL THERAPEUTICS, INC. (New York, NY) 2039-08-18 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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