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Last Updated: January 23, 2021

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Patent: 10,377,824

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Summary for Patent: 10,377,824
Title:Optimization of antibodies that bind lymphocyte activation gene-3 (LAG-3), and uses thereof
Abstract: The present invention provides isolated monoclonal antibodies that specifically bind LAG-3, and have optimized functional properties compared to previously described anti-LAG-3 antibodies, such as antibody 25F7 (US 2011/0150892 A1). These properties include reduced deamidation sites, while still retaining high affinity binding to human LAG-3, and physical (i.e., thermal and chemical) stability. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided, as well as immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies. The present invention also provides methods for detecting LAG-3, as well as methods for treating stimulating immune responses using an anti-LAG-3 antibody of the invention. Combination therapy, in which the antibodies are co-administered with at least one additional immunostimulatory antibody, is also provided.
Inventor(s): Lonberg; Nils (Woodside, CA), Srinivasan; Mohan (Cupertino, CA)
Assignee: Bristol-Myers Squibb Company (Princeton, NJ)
Application Number:16/125,028
Patent Claims:see list of patent claims

Details for Patent 10,377,824

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Bristol Myers Squibb OPDIVO nivolumab INJECTABLE;INJECTION 125554 001 2015-11-23   Start Trial Bristol-Myers Squibb Company (Princeton, NJ) 2032-07-02 RX Orphan search
Bristol Myers Squibb OPDIVO nivolumab INJECTABLE;INJECTION 125527 002 2015-03-04   Start Trial Bristol-Myers Squibb Company (Princeton, NJ) 2032-07-02 RX search
Bristol Myers Squibb OPDIVO nivolumab INJECTABLE;INJECTION 125527 001 2015-03-04   Start Trial Bristol-Myers Squibb Company (Princeton, NJ) 2032-07-02 RX search
Bristol Myers Squibb YERVOY ipilimumab INJECTABLE; INJECTION 125377 001 2011-03-25   Start Trial Bristol-Myers Squibb Company (Princeton, NJ) 2032-07-02 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

International Patent Family for US Patent 10,377,824

Country Patent Number Estimated Expiration
World Intellectual Property Organization (WIPO) 2014008218   Start Trial
Uruguay 34887   Start Trial
United States of America 10266591   Start Trial
United States of America 2014093511   Start Trial
United States of America 2015307609   Start Trial
United States of America 2017137514   Start Trial
>Country >Patent Number >Estimated Expiration

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