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Last Updated: September 22, 2020

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Patent: 10,358,500

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Summary for Patent: 10,358,500
Title:Humanized antibodies that bind LGR5
Abstract: Disclosed herein are humanized anti-LGR5 antibodies for the treatment of cancer. Antibodies disclosed herein may bind LGR5 without disrupting LGR5-RSPO1 binding or signaling, and may disrupt LGR5 signaling through Wnt that is independent of RSPO1. Also disclosed are heavy and light chain polypeptide sequences for the biding of LGR5, for example without disrupting LGR5-RSPO binding or signaling.
Inventor(s): Reyes; Christopher L. (San Diego, CA), Chu; Peter (San Diego, CA), Smith; Kristen M. (San Clemente, CA), Campbell; Lioudmila A. (Del Mar, CA), Shojaei; Farbod (San Diego, CA), Norton; John Thomas (San Diego, CA)
Assignee: BIONOMICS INC. (San Diego, CA)
Application Number:15/379,058
Patent Claims:see list of patent claims

Details for Patent 10,358,500

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Imclone ERBITUX cetuximab VIAL; INTRAVENOUS 125084 001 2004-06-18   Start Trial BIONOMICS INC. (San Diego, CA) 2034-04-04 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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