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Last Updated: September 27, 2020

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Patent: 10,357,472

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Summary for Patent: 10,357,472
Title:Homogenous antibody drug conjugates via enzymatic methods
Abstract: The present application in one aspect provide Fc-containing polypeptide conjugates comprising an Fc-containing polypeptide conjugated to a conjugate moiety, wherein the Fc-containing polypeptide comprises an N-glycosylated Fc region comprising an acceptor glutamine residue flanked by an N-glycosylation site and wherein the conjugate moiety is conjugated to the Fc-containing polypeptide via the acceptor glutamine residue. Also provided are methods of making such Fc-containing polypeptide conjugates by using a wildtype or engineered transglutaminases. Further provided are engineered transglutaminases specifically designed for carrying out such reactions.
Inventor(s): Hu; Sean (West Sacramento, CA), Allen; Lisha (Sacramento, CA)
Assignee: CSPC Dophen Corporation (Sacramento, CA)
Application Number:15/317,907
Patent Claims:see list of patent claims

Details for Patent 10,357,472

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 001 1998-09-25   Start Trial CSPC Dophen Corporation (Sacramento, CA) 2034-06-12 RX Orphan search
Genentech Inc HERCEPTIN HYLECTA trastuzumab; hyaluronidase-oysk INJECTABLE;SUBCUTANEOUS 761106 001 2019-02-28   Start Trial CSPC Dophen Corporation (Sacramento, CA) 2034-06-12 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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