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Generated: September 22, 2019

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Patent: 10,338,039

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Summary for Patent: 10,338,039

Title:	Method for detecting monoclonal antibody using mass spectrometry
Abstract:	A method is provided for more easily detecting and quantifying a protein by regioselectively digesting a variable region of an Fab domain of a monoclonal antibody while suppressing proteolysis of an Fc domain. In the method, a porous body in which a monoclonal antibody is immobilized in pores and nanoparticles on which a protease is immobilized are brought into contact with each other in a liquid to perform selective proteolysis of the monoclonal antibody, and a resulting peptide fragment is detected using liquid chromatography-mass spectrometry (LC-MS), and a peptide having an amino acid sequence that includes an amino acid derived from a CDR2 region of a heavy chain or a light chain of the monoclonal antibody is detected.
Inventor(s):	Shimada; Takashi (Kyoto, JP), Iwamoto; Noriko (Kyoto, JP)
Assignee:	SHIMADZU CORPORATION (Kyoto-shi, JP)
Application Number:	15/556,018
Patent Claims:	see list of patent claims

Details for Patent 10,338,039

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Number	Approval Date	Patent No.	Assignee	Estimated Patent Expiration	Status	Orphan	Source
Genentech	RITUXAN	rituximab	VIAL	103705	001	1997-11-26	Try a Free Trial	SHIMADZU CORPORATION (Kyoto-shi, JP)	2035-03-09	RX		search
Genentech	HERCEPTIN	trastuzumab	VIAL; INTRAVENOUS	103792	001	1998-09-25	Try a Free Trial	SHIMADZU CORPORATION (Kyoto-shi, JP)	2035-03-09	RX	Orphan	search
Genentech	AVASTIN	bevacizumab	VIAL; INTRAVENOUS	125085	001	2004-02-26	Try a Free Trial	SHIMADZU CORPORATION (Kyoto-shi, JP)	2035-03-09	RX		search
Genentech	AVASTIN	bevacizumab	VIAL; INTRAVENOUS	125085	002	2004-02-26	Try a Free Trial	SHIMADZU CORPORATION (Kyoto-shi, JP)	2035-03-09	RX		search
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Number	>Approval Date	>Patent No.	>Assignee	>Estimated Patent Expiration	>Status	>Orphan	>Source

International Patent Family for US Patent 10,338,039

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Country	Patent Number	Publication Date
Brazil	112017017854	Apr 10, 2018
China	107407666	Nov 28, 2017
European Patent Office	3270154	Jan 09, 2019
European Patent Office	3270154	Jan 17, 2018
>Country	>Patent Number	>Publication Date

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