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Last Updated: September 26, 2020

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Patent: 10,337,018

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Summary for Patent: 10,337,018
Title:Asparaginase mutant with efficient expression, activity and stability
Abstract: The present disclosure discloses an asparaginase mutant with efficient expression, activity and stability, belonging to the technical fields of gene engineering and enzyme engineering. The amino acid sequence of the asparaginase mutant is set forth in SEQ ID NO: 99, SEQ ID NO: 100 or SEQ ID NO: 101; meanwhile, compared with the wild type asparaginase mutant, the extracellular enzyme activity of the asparaginase fusion enzyme mutant is increased by up to 2.25 times, the stability is increased by up to 3.56 times, and the specific enzyme activity is increased by up to 1.34 times.
Inventor(s): Liu; Song (Wuxi, CN), Chen; Jian (Wuxi, CN), Du; Guocheng (Wuxi, CN), Zhao; Weixin (Wuxi, CN)
Application Number:16/177,480
Patent Claims:see list of patent claims

Details for Patent 10,337,018

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial JIANGNAN UNIVERSITY (Wuxi, CN) 2039-07-18 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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