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Last Updated: September 20, 2020

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Patent: 10,329,246

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Summary for Patent: 10,329,246
Title:RUNX2 transcription factor inhibitors and uses thereof
Abstract: Provide herein are compounds with a general chemical structure of: ##STR00001## Substituents R.sub.1 and R.sub.2 independently are H, Cl, F, Br, CH.sub.3, CF.sub.3, SH, --N(C.sub.1-3alkyl).sub.2, --NHC(O)C.sub.1-3alkyl, or --NHC(O)C.sub.5-7cycloalkyl, substituent R.sub.3 is H or C.sub.1-3 alkyl and R4 is a bridged cycloalkene such as a bridged cyclohexene or a bridge-substituted cyclohexene. The compounds are therapeutics to treat a cancer, such as breast cancer, or metastatic cancers, to inhibit RUNX2 activity, such as protein expression, in a cancer cell and to increase survival of a subject with breast cancer.
Inventor(s): Passaniti; Antonino (White Hall, MD), Alexander, Jr.; MacKerell D. (Baltimore, MD)
Assignee: University of Maryland, Baltimore (Baltimore, MD) The United States of America as represented by the Department of Veterans Affairs (Washington, DC)
Application Number:15/708,872
Patent Claims:see list of patent claims

Details for Patent 10,329,246

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 001 1998-09-25   Start Trial University of Maryland, Baltimore (Baltimore, MD) The United States of America as represented by the Department of Veterans Affairs (Washington, DC) 2035-03-19 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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