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Last Updated: November 28, 2021

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Patent: 10,329,246

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Summary for Patent: 10,329,246
Title:RUNX2 transcription factor inhibitors and uses thereof
Abstract: Provide herein are compounds with a general chemical structure of: ##STR00001## Substituents R.sub.1 and R.sub.2 independently are H, Cl, F, Br, CH.sub.3, CF.sub.3, SH, --N(C.sub.1-3alkyl).sub.2, --NHC(O)C.sub.1-3alkyl, or --NHC(O)C.sub.5-7cycloalkyl, substituent R.sub.3 is H or C.sub.1-3 alkyl and R4 is a bridged cycloalkene such as a bridged cyclohexene or a bridge-substituted cyclohexene. The compounds are therapeutics to treat a cancer, such as breast cancer, or metastatic cancers, to inhibit RUNX2 activity, such as protein expression, in a cancer cell and to increase survival of a subject with breast cancer.
Inventor(s): Passaniti; Antonino (White Hall, MD), Alexander, Jr.; MacKerell D. (Baltimore, MD)
Assignee: University of Maryland, Baltimore (Baltimore, MD) The United States of America as represented by the Department of Veterans Affairs (Washington, DC)
Application Number:15/708,872
Patent Claims:see list of patent claims

Details for Patent 10,329,246

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 1998-09-25 ⤷  Free Forever Trial 2035-03-19
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 2017-02-10 ⤷  Free Forever Trial 2035-03-19
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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