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Last Updated: March 30, 2023

Patent: 10,323,239


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Summary for Patent: 10,323,239
Title:Serine protease molecules and therapies
Abstract: Cell-targeted serine protease constructs are provided. Such constructs can be used in methods for targeted cell killing such as for treatment cell of proliferative diseases (e.g., cancer). In some aspects, recombinant serine proteases, such as Granzyme B polypeptides, are provided that exhibit improved stability and cell toxicity. Methods and compositions for treating lapatinib or trastuzumab-resistant cancers are also provided.
Inventor(s): Rosenblum; Michael G. (Sugar Land, TX), Mohamedali; Khalid Amanali (Houston, TX), Cheung; Lawrence H. (Houston, TX)
Assignee: Research Development Foundation (Carson City, NV)
Application Number:15/916,743
Patent Claims:see list of patent claims

Details for Patent 10,323,239

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 09/25/1998 ⤷  Sign Up 2032-10-04
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 02/10/2017 ⤷  Sign Up 2032-10-04
Eli Lilly And Company ERBITUX cetuximab Injection 125084 02/12/2004 ⤷  Sign Up 2032-10-04
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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