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Last Updated: February 18, 2020

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Patent: 10,323,083

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Summary for Patent: 10,323,083
Title:Agents that specifically bind matrilin-3 and their use
Abstract: Monoclonal antibodies and antibody fragments that specifically bind to matrilin-3, conjugates including these molecules, and nucleic acid molecules encoding the antibodies, antigen binding fragments and conjugates, are disclosed. Also disclosed are compositions including the disclosed antibodies, antigen binding fragments, conjugates, and nucleic acid molecules. Methods of treating or inhibiting a cartilage disorder in a subject, as well as methods of increasing chondrogenesis in cartilage tissue are further provided. The methods can be used, for example, for treating or inhibiting a growth plate disorder in a subject, such as a skeletal dysplasia or short stature.
Inventor(s): Baron; Jeffrey (Bethesda, MD), Cheung; Crystal Sao Fong (Bethesda, MD), Lui; Julian Chun Kin (Bethesda, MD), Dimitrov; Dimiter (Frederick, MD), Zhu; Zhongyu (Frederick, MD)
Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, DC)
Application Number:15/111,773
Patent Claims:see list of patent claims

Details for Patent 10,323,083

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23   Start Trial The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, DC) 2034-01-15 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23   Start Trial The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, DC) 2034-01-15 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23   Start Trial The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, DC) 2034-01-15 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 004 2015-01-23   Start Trial The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, DC) 2034-01-15 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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