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Generated: July 20, 2019

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Patent: 10,323,083

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Summary for Patent: 10,323,083
Title:Agents that specifically bind matrilin-3 and their use
Abstract: Monoclonal antibodies and antibody fragments that specifically bind to matrilin-3, conjugates including these molecules, and nucleic acid molecules encoding the antibodies, antigen binding fragments and conjugates, are disclosed. Also disclosed are compositions including the disclosed antibodies, antigen binding fragments, conjugates, and nucleic acid molecules. Methods of treating or inhibiting a cartilage disorder in a subject, as well as methods of increasing chondrogenesis in cartilage tissue are further provided. The methods can be used, for example, for treating or inhibiting a growth plate disorder in a subject, such as a skeletal dysplasia or short stature.
Inventor(s): Baron; Jeffrey (Bethesda, MD), Cheung; Crystal Sao Fong (Bethesda, MD), Lui; Julian Chun Kin (Bethesda, MD), Dimitrov; Dimiter (Frederick, MD), Zhu; Zhongyu (Frederick, MD)
Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, DC)
Application Number:15/111,773
Patent Claims:see list of patent claims

Details for Patent 10,323,083

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 004 2015-01-23 ➤ Try a Free Trial The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, DC) ➤ Try a Free Trial RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23 ➤ Try a Free Trial The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, DC) ➤ Try a Free Trial RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23 ➤ Try a Free Trial The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, DC) ➤ Try a Free Trial RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23 ➤ Try a Free Trial The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, DC) ➤ Try a Free Trial RX Orphan search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source

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International Patent Family for US Patent 10,323,083

Country Patent Number Publication Date
World Intellectual Property Organization (WIPO) 2015108998 Jul 23, 2015
World Intellectual Property Organization (WIPO) 2015108998 Jun 23, 2016
World Intellectual Property Organization (WIPO) 2015108998 Oct 22, 2015
United States of America 2016340418 Nov 24, 2016
European Patent Office 3094350 Nov 23, 2016
Canada 2931005 Jul 23, 2015
Country Patent Number Publication Date

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Serving hundreds of leading biopharmaceutical companies globally:

Merck
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Johnson and Johnson
Fuji
Cipla
Citi

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