Means and methods of measuring parathyroid hormone in patients suffering from oxidative stress
A method is disclosed for obtaining an antibody or antibody fragment to a conformational epitope specific for misfolded inactive human parathyroid hormone and fragments thereof. The method includes the steps of a) immunizing an animal with an immunogen which comprises oxidized parathyroid hormone or an oxidized fragment of parathyroid hormone, or both; and b) recovering an antibody, antibody fragments, or single chain antibody. The complementary determining region of the recovered antibody, antibody fragment or single chain antibody is capable of specifically recognizing a conformational epitope (antigenic determinant) which is present on oxidized parathyroid hormone and fragments thereof only but not regular bioactive human parathyroid hormone.
Armbruster; Franz Paul (Bensheim, DE), Hocher; Berthold (Kleinmachnow, DE), Groen; Hans Juergen (Bensheim, DE), Roth; Heinz Juergen (Heidelberg, DE)
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