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Last Updated: October 1, 2020

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Patent: 10,286,008

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Summary for Patent: 10,286,008
Title:Method for stabilising suspensions of red blood cells encapsulating an active ingredient
Abstract: A method for obtaining a stabilized suspension of red blood cells encapsulating an active ingredient, from resealed RBCs incorporating the active ingredient, the method comprising the incubation of the resealed RBCs in an incubation solution at an osmolality of no less than 280 m Osmol/kg, for a time of 30 minutes or more, the incubation solution being a solution that does not contain an agent which is denaturating for the RBC membrane, the liquid medium is then removed from the incubated suspension and the RBCs obtained are placed in suspension in a solution allowing the injection of the suspension in a patient. The suspensions obtained are particularly characterized by an extracellular haemoglobin level maintained at 0.5 or lower, in particular 0.2 g/dl or lower and/or a hemolysis rate maintained at 2 or less, in particular 1% or less, at 72 h after placing in suspension in a preservation solution and at a temperature of between 2 and 8.degree. C.
Inventor(s): Godfrin; Yann (Lyons, FR), Bourgeaux; Vanessa (Lyons, FR), Bailly; Jerome (Chassieu, FR)
Assignee: ERYTECH PHARMA (Lyons, FR)
Application Number:14/889,083
Patent Claims:see list of patent claims

Details for Patent 10,286,008

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial ERYTECH PHARMA (Lyons, FR) 2033-05-07 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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Colorcon
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Baxter

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