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Last Updated: October 26, 2021

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Patent: 10,280,468

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Summary for Patent: 10,280,468
Title:Molecular diagnostic test for predicting response to anti-angiogenic drugs and prognosis of cancer
Abstract: Methods for selecting whether to administer an anti-angiogenic therapeutic agent to a subject include steps of measuring the expression levels of one or more biomarkers selected from Table 2 or Table 3 in a sample from the subject; assessing from the expression levels of the one or more biomarkers whether the sample from the subject is positive or negative for a biomarker signature, wherein if the sample is positive for the biomarker signature an anti-angiogenic therapeutic agent is contraindicated. Related prognostic methods and treatment methods are also provided. The invention is particularly applicable in ovarian and colorectal cancers.
Inventor(s): Harkin; Denis Paul (Dromore, GB), Kennedy; Richard (Belfast, GB), Keating; Katherine E. (Magherafelt, GB), McCavigan; Andrena (Derryadd Lurgan, GB), Hill; Laura A. (Lisburn, GB), Deharo; Steve (Belfast, GB), Davison; Timothy (Hillsborough, GB), Patterson; Fionnuala (Hauxton, GB), Donegan; Sinead (Belfast, GB), Jellema; Gera (Portadown, GB), Gourley; Charlie (Dumfermline, GB)
Assignee: Almac Diagnostics Limited (Craigavon, GB)
Application Number:15/116,641
Patent Claims:see list of patent claims

Details for Patent 10,280,468

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. AVASTIN bevacizumab Injection 125085 2004-02-26 ⤷  Free Forever Trial 2034-05-28
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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