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Generated: July 22, 2019

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Patent: 10,267,754

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Summary for Patent: 10,267,754
Title:Assessing biopharmaceutical aggregation using magnetic resonance relaxometry
Abstract: The present invention generally relates to a method of using NMR relaxation rates (R.sub.2) of water molecules as an indicator of the extent of aggregation of biopharmaceutical formulations. The biopharmaceutical can be evaluated nondestructively without the vial or container being opened or protective seal compromised (i.e., broken). The method is applicable to all biopharmaceuticals and the water signal obtained by magnetic resonance relaxometry is very strong and sensitive because water is used as the solvent and is present in high (>90%) concentrations in every biopharmaceutical formulation.
Inventor(s): Yu; Yihua Bruce (Baltimore, MD), Taraban; Marc (Baltimore, MD), Feng; Yue (Baltimore, MD)
Assignee: UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, MD)
Application Number:14/780,711
Patent Claims:see list of patent claims

Details for Patent 10,267,754

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source
Janssen Biotech STELARA ustekinumab INJECTABLE;INJECTION 761044 001 2016-09-23 ➤ Try a Free Trial UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, MD) ➤ Try a Free Trial RX search
Janssen Biotech SIMPONI ARIA golimumab INJECTABLE; INJECTION 125433 001 2013-07-18 ➤ Try a Free Trial UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, MD) ➤ Try a Free Trial RX search
Amgen XGEVA denosumab INJECTABLE; SUBCUTANEOUS 125320 002 2010-06-01 ➤ Try a Free Trial UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, MD) ➤ Try a Free Trial RX Orphan search
Amgen PROLIA denosumab INJECTABLE; SUBCUTANEOUS 125320 001 2010-06-01 ➤ Try a Free Trial UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, MD) ➤ Try a Free Trial RX Orphan search
Centocor Ortho Biotech Inc SIMPONI golimumab INJECTABLE; INJECTION 125289 001 2009-04-24 ➤ Try a Free Trial UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, MD) ➤ Try a Free Trial RX search
Centocor Ortho Biotech Inc STELARA ustekinumab INJECTABLE; INJECTION 125261 002 2009-12-30 ➤ Try a Free Trial UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, MD) ➤ Try a Free Trial RX search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source

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