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Last Updated: August 11, 2020

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Patent: 10,266,606

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Summary for Patent: 10,266,606
Title:Method for purifying Cys-linked antibody-drug conjugates
Abstract: The present invention relates to a method for purifying a mixture of cysteine-linked antibody-drug conjugates, wherein the amount of non-conjugated antibody is in the range of 0-40% by weight, using hydrophobic interaction chromatography (HIC). The mixture is loaded onto a preparative HIC column using a 0.2-1.5 M aqueous salt solution, in which non-conjugated antibody is collected in a flow-through fraction, followed by elution of a purified mixture of cysteine-linked antibody-drug conjugates using a 0-100 mM aqueous salt solution.
Inventor(s): De Roo; Guy (Nijmegen, NL), Verstegen; Ruud Martin (Nijmegen, NL), Coumans; Rudy Gerardus Elisabeth (Nijmegen, NL)
Assignee: Synthon Biopharmaceuticals B.V. (Nijmegen, NL)
Application Number:15/110,169
Patent Claims:see list of patent claims

Details for Patent 10,266,606

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech Inc HERCEPTIN HYLECTA trastuzumab; hyaluronidase-oysk INJECTABLE;SUBCUTANEOUS 761106 001 2019-02-28   Start Trial Synthon Biopharmaceuticals B.V. (Nijmegen, NL) 2034-01-10 RX search
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 001 1998-09-25   Start Trial Synthon Biopharmaceuticals B.V. (Nijmegen, NL) 2034-01-10 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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