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Last Updated: October 25, 2020

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Patent: 10,258,689

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Summary for Patent: 10,258,689
Title:Stable liquid formulation of etanercept
Abstract: The present invention relates to a stable liquid formulation of etanercept (recombinant p75 sTNFR:Fc fusion protein), and more particularly, to a liquid formulation comprising one or more stabilizers selected from the group consisting of methionine, lysine, histidine, and pharmaceutically acceptable salts thereof in an amount sufficient to reduce by-product formation of etanercept during storage. The liquid formulation according to the present invention effectively reduces production of etanercept by-products and to stably maintain its pharmaceutical efficacies for long-term storage. Therefore, the reconstitution procedure is not required before administration, and the sterile formulation can be administered to patients to ensure patient safety. Thus, it can be applied to the fields in need of etanercept treatment.
Inventor(s): Choi; Suk Young (Daejeon, KR), Ko; Youn Kyung (Daejeon, KR), So; Jin Eon (Daejeon, KR)
Assignee: LG CHEM, LTD. (Seoul, KR)
Application Number:14/123,704
Patent Claims:see list of patent claims

Details for Patent 10,258,689

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Immunex ENBREL etanercept SYRINGE 103795 002 1998-11-02   Start Trial LG CHEM, LTD. (Seoul, KR) 2031-06-03 RX Orphan search
Immunex ENBREL etanercept VIAL; SUBCUTANEOUS 103795 001 1998-11-02   Start Trial LG CHEM, LTD. (Seoul, KR) 2031-06-03 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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