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Last Updated: October 1, 2020

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Patent: 10,246,682

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Summary for Patent: 10,246,682
Title:Methods of culturing retinal pigmented epithelium cells, including Xeno-free production, RPE enrichment, and cryopreservation
Abstract: The production of high quality retinal pigmented epithelium (RPE) cells is necessary for research and potential therapeutic uses. Especially desirable are methods for the production of RPE cells using xeno-free culture conditions. Disclosed herein are novel methods for the production of RPE cells from pluripotent cells with high yields, including xeno-free production methods. Also provided are methods of efficiently isolating RPE cells from cultures containing heterogeneous cell types, allowing for substantially pure RPE cell cultures to be established. Additionally, novel methods for the cryopreservation of RPE cells are provided.
Inventor(s): Clegg; Dennis (Ventura, CA), Hikita; Sherry T. (Santa Barbara, CA), Johnson; Lincoln V. (Santa Barbara, CA), Miller; Liane (San Francisco, CA), Tsie; Marlene (Santa Barbara, CA), Presbrey; Chelsea D. (Flagstaff, AZ), Conti; Lisa R. (Goleta, CA), Maloney; Michelle A. (Santa Barbara, CA), Hinton; David R. (Venice Beach, CA), Hu; Qirui (Santa Barbara, CA)
Assignee: The Regents of the University of California (Oakland, CA) University of Southern California (Los Angeles, CA)
Application Number:15/816,912
Patent Claims:see list of patent claims

Details for Patent 10,246,682

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial The Regents of the University of California (Oakland, CA) University of Southern California (Los Angeles, CA) 2032-02-01 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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