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Last Updated: September 28, 2020

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Patent: 10,246,484

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Summary for Patent: 10,246,484
Title:Method for purifying recombinant protein
Abstract: A method is provided for purifying a recombinant protein from a mixture comprising the recombinant protein and related proteins, comprising the steps of: A. using a first equilibrating buffer in a first conductivity and pH to make the recombinant protein bind to an ion exchange medium; B. using a second equilibration buffer in a second conductivity and pH to continually equilibrate the ion exchange medium bound to the protein; C. using a washing liquid in a third conductivity and a gradually increasing pH to wash the ion-exchange medium, and eluting the first category-related proteins; D. using a first eluent in a fourth conductivity and pH to elute the ion exchange medium, and eluting the target recombinant protein; and E. using a second eluent in a fifth conductivity and pH to continually elute the ion exchange medium, and eluting the second category-related proteins.
Inventor(s): Hu; Hui (Shanghai, CN), Zhu; Yunbin (Shanghai, CN), Zang; Meiling (Shanghai, CN)
Assignee: SUNSHINE GUOJIAN PHARMACEUTICAL (SHANGHAI) CO., LTD. (Shanghai, CN)
Application Number:15/034,821
Patent Claims:see list of patent claims

Details for Patent 10,246,484

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 001 1998-09-25   Start Trial SUNSHINE GUOJIAN PHARMACEUTICAL (SHANGHAI) CO., LTD. (Shanghai, CN) 2033-11-06 RX Orphan search
Genentech PERJETA pertuzumab VIAL; SINGLE-USE 125409 001 2012-06-08   Start Trial SUNSHINE GUOJIAN PHARMACEUTICAL (SHANGHAI) CO., LTD. (Shanghai, CN) 2033-11-06 RX search
Genentech Inc HERCEPTIN HYLECTA trastuzumab; hyaluronidase-oysk INJECTABLE;SUBCUTANEOUS 761106 001 2019-02-28   Start Trial SUNSHINE GUOJIAN PHARMACEUTICAL (SHANGHAI) CO., LTD. (Shanghai, CN) 2033-11-06 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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Express Scripts

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