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Last Updated: September 24, 2020

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Patent: 10,214,590

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Summary for Patent: 10,214,590
Title:Inhibitors of endoglin activity for the treatment of fibrosis
Abstract: Endoglin has been identified to play a functional role as a regulator of TGF.beta.1 signaling, particular in TGF.beta.1-mediated calcineurin expression. The present invention features methods of reducing cardiac damage, particularly in a subject undergoing chemotherapy or radiation therapy by administering a composition that inhibits endoglin activity. The present invention also features methods of treating autoimmune diseases, inflammatory diseases, organ transplantation, and conditions association with oxidative stress related to TGF.beta.1-mediated calcineurin expression and reactive oxygen species (ROS) production by administering a composition that inhibits endoglin activity. The present invention also features methods of treating fibrotic diseases by administering a composition that inhibits endoglin activity.
Inventor(s): Kapur; Navin K. (Hanover, MA), Karas; Richard H. (Franklin, MA)
Assignee: Tufts Medical Center, Inc. (Boston, MA)
Application Number:15/022,663
Patent Claims:see list of patent claims

Details for Patent 10,214,590

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Centocor Inc REMICADE infliximab VIAL 103772 001 1998-08-24   Start Trial Tufts Medical Center, Inc. (Boston, MA) 2033-09-20 RX Orphan search
Immunex ENBREL etanercept VIAL; SUBCUTANEOUS 103795 001 1998-11-02   Start Trial Tufts Medical Center, Inc. (Boston, MA) 2033-09-20 RX Orphan search
Immunex ENBREL etanercept SYRINGE 103795 002 1998-11-02   Start Trial Tufts Medical Center, Inc. (Boston, MA) 2033-09-20 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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