Last Updated: May 21, 2026

Patent: 10,208,101

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Summary for Patent: 10,208,101

Title:	Recombinant fibrinogen high-production line and method for producing same
Abstract:	The present invention provides a recombinant strain highly producing fibrinogen which is an animal cell strain coexpressing a fibrinogen and an .alpha.2PI and/or PAI-2, genes encoding A.alpha. chain, B.beta. chain and .gamma. chain of fibrinogen, a production method of a recombinant strain highly producing fibrinogen, including introducing gene(s) encoding .alpha.2PI and/or PAI-2 into an animal cell, and coexpressing fibrinogen and .alpha.2PI and/or PAI-2 in the animal cell, and a production method of a recombinant fibrinogen including culturing a recombinant strain highly producing fibrinogen in a medium, and recovering fibrinogen from the obtained culture.
Inventor(s):	Uno; Shusei (Tokyo, JP), Otaki; Momoko (Tokyo, JP), Murakami; Kouji (Tokyo, JP), Ideno; Shoji (Tokyo, JP)
Assignee:	JAPAN BLOOD PRODUCTS ORGANIZATION (Tokyo, JP)
Application Number:	15/108,194
Patent Claims:	see list of patent claims

Details for Patent 10,208,101

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Csl Behring Gmbh	RIASTAP	fibrinogen concentrate (human)	For Injection	125317	January 16, 2009	⤷ Start Trial	2034-12-26
Octapharma Pharmazeutika Produktionsges.m.b.h.	FIBRYGA	fibrinogen (human)	For Injection	125612	June 07, 2017	⤷ Start Trial	2034-12-26
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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