Patent: 10,189,903

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Summary for Patent: 10,189,903

Title:	Bispecific chimeric antigen receptors and methods of use thereof to treat cancer
Abstract:	The invention is directed to a bispecific chimeric antigen receptor, comprising: (a) at least two antigen-specific targeting regions; (b) an extracellular spacer domain; (c) a transmembrane domain; (d) at least one co-stimulatory domain; and (e) an intracellular signaling domain, wherein each antigen-specific targeting region comprises an antigen-specific single chain Fv (scFv) fragment, and binds a different antigen, and wherein the bispecific chimeric antigen receptor is co-expressed with a therapeutic control. The invention also provides methods and uses of the bispecific chimeric antigen receptors.
Inventor(s):	Jensen; Michael (Bainbridge, WA)
Assignee:	Seattle Children\'s Hospital (Seattle, WA)
Application Number:	15/233,140
Patent Claims:	see list of patent claims

Details for Patent 10,189,903

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Number	Approval Date	Patent No.	Assignee	Estimated Patent Expiration	Status	Orphan	Source
Imclone	ERBITUX	cetuximab	VIAL; INTRAVENOUS	125084	001	2004-06-18	Try a Free Trial	Seattle Children\'s Hospital (Seattle, WA)	2032-02-13	RX	Orphan	search
Genentech	HERCEPTIN	trastuzumab	VIAL; INTRAVENOUS	103792	001	1998-09-25	Try a Free Trial	Seattle Children\'s Hospital (Seattle, WA)	2032-02-13	RX	Orphan	search
Genentech	RITUXAN	rituximab	VIAL	103705	001	1997-11-26	Try a Free Trial	Seattle Children\'s Hospital (Seattle, WA)	2032-02-13	RX		search
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Number	>Approval Date	>Patent No.	>Assignee	>Estimated Patent Expiration	>Status	>Orphan	>Source

International Patent Family for US Patent 10,189,903

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Country	Patent Number	Publication Date
World Intellectual Property Organization (WIPO)	2013123061	Aug 22, 2013
United States of America	2015038684	Feb 05, 2015
United States of America	2017107285	Apr 20, 2017
United States of America	2019119382	Apr 25, 2019
United States of America	9447194	Sep 20, 2016
>Country	>Patent Number	>Publication Date

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