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Last Updated: December 7, 2021

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Patent: 10,189,797

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Summary for Patent: 10,189,797
Title:Chemical modulators of immune checkpoints and therapeutic use
Abstract: Compounds and pharmaceutical compositions that down-regulate immune checkpoints such as PD-1, PD-L1 and CTLA-4 are provided. Also provided are methods of treating a disease by down-regulating immune checkpoints such as PD-1, PD-L1 and CTLA-4. The methods are useful for treating cancer and viral infection in a subject.
Inventor(s): Chen; Wei (Chapel Hill, NC), Lyerly; Herbert Kim (Chapel Hill, NC), Ren; Xiu-rong (Durham, NC), Wang; Jiangbo (Durham, NC), Guo; Hongtao (Durham, NC), Hobeika; Amy (Durham, NC), Mook; Robert A. (Chapel Hill, NC)
Assignee: Duke University (Durham, NC)
Application Number:15/395,464
Patent Claims:see list of patent claims

Details for Patent 10,189,797

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 1998-09-25 ⤷  Try it Free 2035-12-30
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 2017-02-10 ⤷  Try it Free 2035-12-30
Eli Lilly And Company ERBITUX cetuximab Injection 125084 2004-02-12 ⤷  Try it Free 2035-12-30
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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Serving leading biopharmaceutical companies globally:

AstraZeneca
Express Scripts
Dow
Colorcon
Boehringer Ingelheim
Baxter

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