Stabilized STAT3 decoy oligonucleotides and uses therefor
The present invention is based, at least in part, on novel, unimolecular STAT3 oligonucleotide decoys exhibiting increased in vivo stability as compared to previously known decoys which are effective in inhibiting STAT3 when administered systemically. The invention is also based on pharmaceutical compositions comprising these unimolecular decoys, and methods for using these decoys in the treatment of cancer.
Grandis; Jennifer R. (Pittsburgh, PA), Johnson; Daniel E. (Glenshaw, PA), Ly; Danith (Pittsburgh, PA)
UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, PA) CARNEGIE MELLON UNIVERSITY (Pittsburgh, PA)
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