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Last Updated: September 27, 2020

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Patent: 10,183,968

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Summary for Patent: 10,183,968
Title:Methods of preparing lyophilized spherical-shaped pellets of biological materials
Abstract: Methods for preparing lyophilized pellets of biological materials are described. The pellets have a substantially spherical shape and are prepared by freezing droplets of a liquid composition of a desired biological material on a flat, solid surface, in particular, a surface that does not have any cavities, followed by lyophilizing the frozen droplets. These methods are useful for preparing lyophilized pellets having a high concentration of a desired biological material, in particular a therapeutic protein or vaccine, and which have a faster reconstitution time than lyophilized powder cakes prepared in vials.
Inventor(s): Barr; Colleen (Pennsburg, PA), Bhambhani; Akhilesh (Doylestown, PA), Evans; Robert (Souderton, PA), Isopi; Lynne (Sellersville, PA), Krah; David (Lansdale, PA), Kriss; Jennifer (Blue Bell, PA), Sinacola; Jessica (Collegeville, PA)
Assignee: Merck Sharp & Dohme Corp. (Rahway, NJ)
Application Number:14/355,405
Patent Claims:see list of patent claims

Details for Patent 10,183,968

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck Sharp & Dohme Corp. ZOSTAVAX zoster vaccine live INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION 125123 001 2006-05-25   Start Trial Merck Sharp & Dohme Corp. (Rahway, NJ) 2031-10-31 search
Merck Sharp & Dohme Corp. ZOSTAVAX zoster vaccine live INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION 125123 1 2006-05-25   Start Trial Merck Sharp & Dohme Corp. (Rahway, NJ) 2031-10-31 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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